Why does it change? In my experience most people keep their first cell phone number for their entire lives. Area codes are indicative of nothing, except where you lived in 2005 [1].
Not everyone lives in the US. Here's how this affects me:
* If I lose my phone, I've permanently lost my number.
* Long-distance calls are a lot more expensive (about 5-10x as much).
* Switch companies? Number lost again.
I've had about 5-6 mobile numbers since during the last decade.
I went to school and got a new number because a lot of my friends didn't have free province-wide calling and I'm about to move from Canada to Europe. So for me this is a particular concern at the moment.
[1] https://xkcd.com/1129/